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Pharmacology



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Pharmacology - Health - 15.04.2019
Statins fail to lower cholesterol in over half of all patients
Experts have warned a more tailored approach is needed to the prescribing of statins, following a new study suggesting they are ineffective at lowering cholesterol to target levels in more than half of patients. The research by primary care experts at The University of Nottingham, which is published in Heart , found that 51.2 per cent of patients prescribed statins saw little benefit to their cholesterol levels within two years, leading to a significant risk of developing cardiovascular disease in the future.

Health - Pharmacology - 11.04.2019
Bristol part of ¤20.8M study to drive drug discovery for atopic dermatitis and psoriasis
Bristol part of ¤20.8M study to drive drug discovery for atopic dermatitis and psoriasis
The lives of patients affected by atopic dermatitis and psoriasis could be improved thanks to the start of an EU-funded research project BIOMAP (Biomarkers in Atopic Dermatitis and Psoriasis). The five-year project will address key unmet needs in treating these common inflammatory skin conditions by analysing data from more than 50 000 patients to improve disease understanding, patient care and future therapies.

Pharmacology - Life Sciences - 10.04.2019
Active lifestyles may help nerves to heal after spinal injuries
Active lifestyles may help nerves to heal after spinal injuries
Leading an active lifestyle may increase the likelihood of damaged nerves regenerating after a spinal cord injury. The early-stage findings , published in the journal Science Translational Medicine , come from studies in mice and rats with spinal cord injuries, in which scientists uncovered a mechanism for nerve fibres repairing after they had been damaged.

Pharmacology - Health - 05.04.2019
New target for development of drugs to fight viruses
Researchers at Cardiff University have discovered that a molecule responsible for guiding virus-killing T-cells to the site of infection is also responsible for rapidly increasing T-cell numbers to fight infection, making it an important new target for the development of more effective drugs to treat both viruses and cancers.

Life Sciences - Pharmacology - 04.04.2019
Scientists fine-tune signalling pathways to tweak responses to stimuli in yeast
Scientists fine-tune signalling pathways to tweak responses to stimuli in yeast
Imperial academics have streamlined a signalling pathway in yeast to understand how cell sensing can be tuned by changing protein levels. The research , published in Cell , could eventually help us understand drug side effects in humans, and has immediate implications for biotechnology research. G-protein coupled receptors (GPCRs) are proteins which let cells detect chemical substances like hormones, poisons, and drugs in their environment.

Pharmacology - Life Sciences - 26.03.2019
New 'pulsing' ultrasound technique improves drug delivery to brains of mice
New ’pulsing’ ultrasound technique improves drug delivery to brains of mice
Using rapid short-pulse sequences of ultrasound helps drugs reach the brains of mice, according to new Imperial College London research. Scientists currently use long-wave pulses of ultrasound to deliver drugs, which can cause side effects. Now, these new findings from Imperial on shorter-wave pulses could change how drugs are used to help patients of Alzheimer's and other neurological diseases.

Health - Pharmacology - 22.03.2019
Bringing a new generation of drugs to patients
Bringing a new generation of drugs to patients
Cardiff University is stepping up the development of new drugs for mental health and central nervous system conditions, with the launch of the Medicines Discovery Institute. Focusing on areas of unmet clinical need, the new institute will develop novel medications to improve the lives of people across the world.

Pharmacology - Health - 18.03.2019
Caterpillars could hold the secret to new treatment for Osteoarthritis
A substance from a fungus that infects caterpillars could offer new treatment hope for sufferers of osteoarthritis according to new research. Cordycepin is an active compound isolated from the caterpillar fungus Cordyceps militaris and has proved to be effective in treating osteoarthritis by blocking inflammation in a new way, through reducing a process called polyadenylation.

Pharmacology - Health - 13.03.2019
New cholesterol-lowering drug could help patients unable to take statins
New cholesterol-lowering drug could help patients unable to take statins
A new class of oral cholesterol-lowering drug could help patients unable to take statins due to side effects. The findings come from the largest study to date to test the effectiveness and safety of bempedoic acid, an oral medication - yet to be approved in Europe - which inhibits the body's ability to create the building blocks of cholesterol.

Pharmacology - Health - 13.03.2019
Molecular patterns could better predict breast cancer recurrence
The genetic and molecular make-up of individual breast tumours holds clues to how a woman's disease could progress, including the likelihood of it coming back after treatment, and in what time frame, according to a study published in Nature.

Pharmacology - Health - 07.03.2019
Potential new treatment for heart attack
Scientists have found a potential new drug for treating the heart damage caused by a heart attack - by targeting the way the heart reacts to stress. This is the finding of new research, by scientists at Imperial College London and published in the journal Cell Stem Cell. There are no existing therapies that directly address the problem of muscle cell death Professor Michael Schneider Study author The research team, part-funded by the British Heart Foundation (BHF) used stem cells to grow heart tissue and mimic a ‘heart attack in a dish'.

Health - Pharmacology - 06.03.2019
New Hepatitis C cases down by almost 70 per cent in HIV positive men in London
New cases of hepatitis C amongst HIV positive men in London have fallen by nearly 70 per cent in recent years. The new analysis of data from three clinics in London found 256 men were diagnosed between 2013-2018. New infections peaked at 17 for every 1000 people studied in 2015 and fell to six by 2018.

Pharmacology - Health - 05.03.2019
HIV remission achieved in second patient
A second person has experienced sustained remission from HIV-1 after ceasing treatment, reports a paper led by UCL and Imperial College London. The case report comes ten years after the first such case, known as the ‘Berlin Patient.' Both patients were treated with stem cell transplants from donors carrying a genetic mutation that prevents expression of an HIV receptor CCR5.

Life Sciences - Pharmacology - 05.03.2019
Could genetic breakthrough finally help take the sting out of mouth ulcers?
A large breakthrough has been made in the genetic understanding of mouth ulcers which could provide potential for a new drug to prevent or heal the painful lesions. Mouth ulcers affect up to 25 per cent of young adults and a higher proportion of children. Previous research has shown that mouth ulcers are partially heritable, but until now there has been little evidence linking specific genes or genomic regions to mouth ulcers.

Pharmacology - Health - 05.03.2019
HIV remission achieved in second patient
HIV remission achieved in second patient
A second person has experienced sustained remission from HIV-1 after ceasing treatment, according to a study published today in Nature.

Health - Pharmacology - 05.03.2019
’Test and Treat’ reduces new HIV infections by a third in African communities
Results from largest ever HIV prevention trial suggest strategy could make a significant contribution to controlling epidemic New HIV infections in southern Africa could be reduced substantially by offering entire communities voluntary HIV testing, and immediately referring those who test positive for HIV treatment in line with local guidelines, according to new research presented at the Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle, USA today.

Pharmacology - Health - 04.03.2019
’Game changer’ in treatment of chronic lymphocytic leukaemia
The first test to quickly and accurately predict how people will respond to standard treatment for the most common type of leukaemia has been developed at Cardiff University. The technology could guide doctors' decisions on which drugs to give to patients. The Cardiff researchers say that the test could now be a ‘game changer' in the treatment of chronic lymphocytic leukaemia (CLL).

Pharmacology - Health - 28.02.2019
Majority of bipolar patients missing out on the most effective treatments
A quarter of patients with bipolar disorder in Scotland are being prescribed medication that could make symptoms worse and cause serious episodes of mania. The research, led by the University of Glasgow and published today in the British Journal of Psychiatry , reveals that many patients with bipolar disorder in Scotland are on combinations of medication treatments that are out of line with recommended clinical guidelines.

Pharmacology - Health - 27.02.2019
Antibiotic prescribing in primary care
New research on when and how GPs should prescribe antibiotics for common infections is published in The BMJ today [Wednesday 27 February] and is accompanied by an editorial response from the University of Bristol's Centre for Academic Primary Care (CAPC). Primary care is responsible for around 80 per cent of all health service antibiotic prescribing in the UK, with rates likely to be similar worldwide.

Pharmacology - Health - 27.02.2019
Early use of antibiotics in elderly patients associated with reduced sepsis risk
Prescribing antibiotics immediately for elderly patients with urinary tract infections is linked with a reduced risk of sepsis and death. These are the latest findings from researchers at Imperial College London and Public Health England , published in the BMJ.
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