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Pharmacology



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Health - Pharmacology - 23.05.2019
Trial of potential new treatment for type 1 diabetes
Researchers at Cardiff and Swansea Universities are running a new trial to investigate whether a medicine currently used for the skin condition psoriasis could also be used to help people with type 1 diabetes produce some of their own insulin. Over 300,000 people in the UK have Type 1 diabetes and the drug used to treat them - insulin - has not changed in 98 years.

Pharmacology - Life Sciences - 20.05.2019
New method simplifies the search for protein receptor complexes, speeding drug development
For a drug to intervene in cells or entire organs that are not behaving normally, it must first bind to specific protein receptors in the cell membranes. Receptors can change their molecular structure in a multitude of ways during binding - and only the right structure will “unlock” the drug's therapeutic effect.

Pharmacology - Health - 14.05.2019
Decoy antibiotics could get around bacteria's defences
Decoy antibiotics could get around bacteria’s defences
Imperial medical students have helped to devise a new type of 'decoy' drug to tackle infections that are resistant to antibiotics. In tests with cell cultures, the new drug successfully killed a strain of drug-resistant bacteria. It works by delivering two antibiotics, one of which is effectively hidden.

Health - Pharmacology - 09.05.2019
Smart design could prevent drug resistance in new malaria treatments
Smart design could prevent drug resistance in new malaria treatments
Researchers have overcome malaria parasites' resistance to potential new drugs by studying how it evolves. In a paper published today in Cell Chemical Biology , scientists from the Francis Crick Institute and Imperial College London studied malaria parasites resistant to a promising new class of candidate antimalarial drugs.

Life Sciences - Pharmacology - 30.04.2019
Offers insight into the proteins in the brain that detect cannabis
Offers insight into the proteins in the brain that detect cannabis
Researchers at the University of Bristol have made new progress in understanding how cannabinoid receptors (CB1Rs), the proteins that detect the active components of marijuana, are controlled in the brain. The brain contains about 100 billion nerve cells that are constantly communicating with one another at specialised junctions called synapses.

Health - Pharmacology - 26.04.2019
Imperial launches world's first Centre for Psychedelics Research
Imperial launches world’s first Centre for Psychedelics Research
The first formal centre for psychedelic research in the world will launch at Imperial College London today. Funded by more than 3 million from five founding donors, the new Imperial Centre for Psychedelic Research will build on over a decade of pioneering work in this area carried out at Imperial, including a clinical trial that has kick-started global efforts to develop psilocybin therapy into a licensed treatment for depression.

Pharmacology - Health - 25.04.2019
Researchers in international drive to develop safer drugs
Medical researchers at the University of Nottingham and NIHR Nottingham Biomedical Research Centre are part of a major new international research project to improve the safety and regulation in the development of drugs. The team of experts in drug-induced liver injury will be members of the Translational Safety Biomarker Pipeline (TransBioLine) - a pioneering project which will generate data to support the development of novel safety biomarkers for five target organ systems (kidney, liver, pancreas, vascular and central nervous system) for use in drug development.

Pharmacology - Health - 15.04.2019
Statins fail to lower cholesterol in over half of all patients
Experts have warned a more tailored approach is needed to the prescribing of statins, following a new study suggesting they are ineffective at lowering cholesterol to target levels in more than half of patients. The research by primary care experts at The University of Nottingham, which is published in Heart , found that 51.2 per cent of patients prescribed statins saw little benefit to their cholesterol levels within two years, leading to a significant risk of developing cardiovascular disease in the future.

Health - Pharmacology - 11.04.2019
Bristol part of 20.8M study to drive drug discovery for atopic dermatitis and psoriasis
Bristol part of 20.8M study to drive drug discovery for atopic dermatitis and psoriasis
The lives of patients affected by atopic dermatitis and psoriasis could be improved thanks to the start of an EU-funded research project BIOMAP (Biomarkers in Atopic Dermatitis and Psoriasis). The five-year project will address key unmet needs in treating these common inflammatory skin conditions by analysing data from more than 50 000 patients to improve disease understanding, patient care and future therapies.

Pharmacology - Life Sciences - 10.04.2019
Active lifestyles may help nerves to heal after spinal injuries
Active lifestyles may help nerves to heal after spinal injuries
Leading an active lifestyle may increase the likelihood of damaged nerves regenerating after a spinal cord injury. The early-stage findings , published in the journal Science Translational Medicine , come from studies in mice and rats with spinal cord injuries, in which scientists uncovered a mechanism for nerve fibres repairing after they had been damaged.

Pharmacology - Health - 05.04.2019
New target for development of drugs to fight viruses
Researchers at Cardiff University have discovered that a molecule responsible for guiding virus-killing T-cells to the site of infection is also responsible for rapidly increasing T-cell numbers to fight infection, making it an important new target for the development of more effective drugs to treat both viruses and cancers.

Life Sciences - Pharmacology - 04.04.2019
Scientists fine-tune signalling pathways to tweak responses to stimuli in yeast
Scientists fine-tune signalling pathways to tweak responses to stimuli in yeast
Imperial academics have streamlined a signalling pathway in yeast to understand how cell sensing can be tuned by changing protein levels. The research , published in Cell , could eventually help us understand drug side effects in humans, and has immediate implications for biotechnology research. G-protein coupled receptors (GPCRs) are proteins which let cells detect chemical substances like hormones, poisons, and drugs in their environment.

Pharmacology - Life Sciences - 26.03.2019
New 'pulsing' ultrasound technique improves drug delivery to brains of mice
New ’pulsing’ ultrasound technique improves drug delivery to brains of mice
Using rapid short-pulse sequences of ultrasound helps drugs reach the brains of mice, according to new Imperial College London research. Scientists currently use long-wave pulses of ultrasound to deliver drugs, which can cause side effects. Now, these new findings from Imperial on shorter-wave pulses could change how drugs are used to help patients of Alzheimer's and other neurological diseases.

Health - Pharmacology - 22.03.2019
Bringing a new generation of drugs to patients
Bringing a new generation of drugs to patients
Cardiff University is stepping up the development of new drugs for mental health and central nervous system conditions, with the launch of the Medicines Discovery Institute. Focusing on areas of unmet clinical need, the new institute will develop novel medications to improve the lives of people across the world.

Pharmacology - Health - 18.03.2019
Caterpillars could hold the secret to new treatment for Osteoarthritis
A substance from a fungus that infects caterpillars could offer new treatment hope for sufferers of osteoarthritis according to new research. Cordycepin is an active compound isolated from the caterpillar fungus Cordyceps militaris and has proved to be effective in treating osteoarthritis by blocking inflammation in a new way, through reducing a process called polyadenylation.

Pharmacology - Health - 13.03.2019
New cholesterol-lowering drug could help patients unable to take statins
New cholesterol-lowering drug could help patients unable to take statins
A new class of oral cholesterol-lowering drug could help patients unable to take statins due to side effects. The findings come from the largest study to date to test the effectiveness and safety of bempedoic acid, an oral medication - yet to be approved in Europe - which inhibits the body's ability to create the building blocks of cholesterol.

Pharmacology - Health - 13.03.2019
Molecular patterns could better predict breast cancer recurrence
The genetic and molecular make-up of individual breast tumours holds clues to how a woman's disease could progress, including the likelihood of it coming back after treatment, and in what time frame, according to a study published in Nature.

Pharmacology - Health - 07.03.2019
Potential new treatment for heart attack
Scientists have found a potential new drug for treating the heart damage caused by a heart attack - by targeting the way the heart reacts to stress. This is the finding of new research, by scientists at Imperial College London and published in the journal Cell Stem Cell. There are no existing therapies that directly address the problem of muscle cell death Professor Michael Schneider Study author The research team, part-funded by the British Heart Foundation (BHF) used stem cells to grow heart tissue and mimic a ‘heart attack in a dish'.

Health - Pharmacology - 06.03.2019
New Hepatitis C cases down by almost 70 per cent in HIV positive men in London
New cases of hepatitis C amongst HIV positive men in London have fallen by nearly 70 per cent in recent years. The new analysis of data from three clinics in London found 256 men were diagnosed between 2013-2018. New infections peaked at 17 for every 1000 people studied in 2015 and fell to six by 2018.

Pharmacology - Health - 05.03.2019
HIV remission achieved in second patient
A second person has experienced sustained remission from HIV-1 after ceasing treatment, reports a paper led by UCL and Imperial College London. The case report comes ten years after the first such case, known as the ‘Berlin Patient.' Both patients were treated with stem cell transplants from donors carrying a genetic mutation that prevents expression of an HIV receptor CCR5.
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