Research Associate in Integrated Catalysis

     
Employer
University of Manchester
Manchester Institute of Biotechnology (MIB)
Published
Closing Date
WorkplaceManchester, North West England, UK
Category
Position

Applications are invited for a Postdoctoral Research Associate to work within the Manchester Institute of Biotechnology (MIB, ?url=http%3A%2F%2Fwww.mib.ac.uk&module=jobs&id=132496" target="_blank" rel="nofollow">www.mib.ac.uk), for three years starting from April 2018. The position is funded by the BBSRC and is led by Prof. Jason Micklefield in collaboration with Profs Michael Greaney, Perdita Barran and David Leys.

Recently we provided the first demonstration of how halogenase enzymes can be combined with chemocatalysts to afford regioselective and regiodivergent arylation and alkenylation of aromatic scaffolds. These one-pot chemobiotransformations combine the power of enzymatic C-H activation with transition metal catalysed cross-coupling chemistry to effect reactions that are not possible using biocatalysts or chemocatalysts alone: see: Nature Commun . 2016 , 7, 11873 (?url=http%3A%2F%2Fwww.nature.com%2Farticles%2Fncomms11873&module=jobs&id=132496" target="_blank" rel="nofollow">www.nature.com/articles/ncomms11873).

Description

In this project we will develop new methodologies for integrating halogenases with chemocatalysis, developing new enzymatic C-H activation reactions enabling regioselective fluorination, trifluoro-methylation, amination and other transformations which are currently inaccessible using existing methods delivering products that are important for pharmaceutical, agrochemical and other industries.

You will join a large interdisciplinary team of chemists and biologists and must hold a PhD, or have equivalent postdoctoral experience in synthetic and bio-organic chemistry, with knowledge of chemocatalysis and biocatalysis.

Requirements

You will join a large interdisciplinary team of chemists and biologists and must hold a PhD, or have equivalent postdoctoral experience in synthetic and bio-organic chemistry, with knowledge of chemocatalysis and biocatalysis.

We offer

£31,604 - £38,833 per annum, depending on experience
Fixed Term - 3 years starting as soon as possible

The School is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance. We particularly welcome applications from women for this post. Appointment will always be made on merit. For further information, please visit:http: ?url=http%3A%2F%2Fwww.chemistry.manchester.ac.uk%2Fabout-us%2Fathena-swan%2F&module=jobs&id=132496" target="_blank" rel="nofollow">www.chemistry.manchester.ac.uk/about-us/athena-swan/

Address

Enquiries about the vacancy :
  • Vacancy, shortlisting and interviews: Prof.Jason Micklefield at jason.micklefieldmanchester.ac.uk or 0161 306 4509 or Prof. Michael Greaney at michael.greaneymanchester.ac.uk or 0161 275 1310.
  • General enquiries: hrservicesmanchester.ac.uk or 0161 275 4499.
  • Technical support: universityofmanchesterhelpmeapply.co.uk or 0161 850 2004

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.

To apply, please click on the apply button to visit our website.

Closing date: 11 April 2018 at midnight.

Web www.manchester.ac.uk
In your application, please quote reference  S&E-11603.